Vidalista 80 mg – Tadalafil Tablets IP 80 mg

Vidalista 80 mg – Tadalafil Tablets IP 80 mg | Advanced Erectile Dysfunction Treatment

Manufacturer: Centurion Remedies Pvt. Ltd.
Composition: Tadalafil 80 mg
Form: Film-coated tablet
Packaging: 10 × 10 tablets
Prescription: Required

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Product Overview

Vidalista 80 mg is a high-strength phosphodiesterase-type-5 (PDE-5) inhibitor containing Tadalafil 80 mg as the active pharmaceutical ingredient. It is clinically formulated to manage erectile dysfunction (ED) and improve erectile response in adult males.

Tadalafil, the pharmacologically active component, enhances penile blood flow by inhibiting PDE-5, the enzyme responsible for degradation of cyclic guanosine monophosphate (cGMP) within the corpus cavernosum. This leads to smooth-muscle relaxation, vasodilation, and improved erectile rigidity in response to sexual stimulation.

Vidalista 80 mg is produced under strict quality standards by Centurion Remedies Pvt. Ltd., India, ensuring consistent potency, safety, and bioavailability.

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Mechanism of Action

Tadalafil is a selective and reversible inhibitor of cyclic GMP-specific phosphodiesterase type 5. Sexual stimulation triggers nitric-oxide release in the corpus cavernosum, activating guanylate cyclase and increasing cGMP concentrations. The elevation of cGMP relaxes smooth-muscle tissue, allowing increased arterial inflow and restricted venous outflow within the penis—producing a natural erection.

By blocking PDE-5, Vidalista 80 mg sustains cGMP levels for longer durations, resulting in improved erection quality and prolonged erectile response.

Tadalafil exhibits a longer half-life (~36 hours) compared to other PDE-5 inhibitors, earning it the designation “weekend pill.” This extended activity provides greater spontaneity and flexibility for sexual activity without the need for frequent dosing.

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Clinical Indications

1. Erectile Dysfunction (ED) – Primary indication. Restores natural erectile ability in adult males by enhancing hemodynamic response to sexual stimulation.

2. Benign Prostatic Hyperplasia (BPH) – In certain cases, tadalafil is used to alleviate lower-urinary-tract symptoms (off-label at lower doses).

3. Combined ED + BPH Management – May be beneficial in patients experiencing both conditions (only under physician supervision).

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Dosage and Administration

• Recommended dosage: One tablet (Tadalafil 80 mg) taken orally with water approximately 30 to 45 minutes prior to anticipated sexual activity.

• Maximum frequency: Once per 24 hours.

• Route of administration: Oral.

• Food effect: May be taken with or without food; a high-fat meal may slightly delay onset.

• Duration of effect: Up to 36 hours post-dose.

Important: Dose must be individualized according to medical evaluation, age, comorbidities, and concurrent pharmacotherapy. Patients must strictly adhere to physician guidance to prevent adverse reactions or excessive vasodilation.

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Key Features of Vidalista 80 mg

1. High-Potency Tadalafil (80 mg): Provides robust efficacy for moderate-to-severe erectile dysfunction.

2. Extended Duration (up to 36 hours): Offers prolonged readiness and flexibility.

3. Clinically Proven PDE-5 Inhibitor: Demonstrated safety and efficacy across multiple controlled trials.

4. Film-Coated Tablet Form: Facilitates easy swallowing and rapid disintegration.

5. Manufactured by Centurion Remedies: Trusted Indian pharmaceutical company compliant with WHO-GMP standards.

6. Stable Pharmacokinetics: Predictable absorption and consistent therapeutic outcomes.

7. Enhanced Patient Confidence: Promotes restored sexual health and psychological well-being.

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Pharmacological Profile

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Therapeutic Benefits

1. Restores Natural Erectile Function

Vidalista 80 mg directly addresses the underlying hemodynamic dysfunction in ED by improving penile arterial flow and smooth-muscle relaxation, thereby restoring physiological erectile capability.

2. Enhances Quality of Sexual Life

Sustained efficacy for up to 36 hours allows greater freedom and confidence, reducing performance anxiety and improving overall sexual satisfaction for both partners.

3. Long-Acting PDE-5 Inhibition

Compared to shorter-acting agents such as sildenafil, tadalafil’s prolonged half-life provides extended efficacy, minimizing the need for precise timing.

4. Well-Tolerated Clinical Profile

Clinical data support the safety of tadalafil when administered as directed. Common adverse events are generally mild and transient.

5. Psychological Reinforcement

Improved erectile performance contributes to restored self-esteem, reduced anxiety, and enhanced relationship quality.

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Target Audience

• Adult males aged 18 – 65 years diagnosed with erectile dysfunction due to psychogenic, organic, or mixed etiologies.

• Patients requiring long-acting pharmacologic management of ED.

• Individuals seeking reliable and well-studied PDE-5 therapy prescribed by a licensed physician.

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Problem Addressed

Erectile dysfunction (ED)—also known as impotence—is characterized by the persistent inability to achieve or sustain an erection sufficient for satisfactory sexual performance. It commonly results from vascular insufficiency, neurogenic disorders, hormonal imbalance, medication side effects, or psychological stressors.

Vidalista 80 mg targets the vascular and smooth-muscle dysfunction central to ED by restoring nitric-oxide–mediated cGMP signaling and improving cavernosal blood flow.

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Desired Outcomes / Benefits

• Restoration of spontaneous, firm erections in response to sexual stimulation

• Increased penile rigidity and duration of erection

• Improved sexual confidence and performance consistency

• Enhanced overall quality of sexual life and intimate relationships

• Reduction in anxiety and psychological distress associated with ED

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Precautions and Contraindications

Contraindications

• Hypersensitivity to Tadalafil or any tablet component

• Concurrent use with organic nitrates (e.g., nitroglycerin) or guanylate cyclase stimulators (e.g., riociguat)

• Patients with severe cardiovascular disorders, recent myocardial infarction, or stroke

• Severe hepatic or renal impairment (without medical supervision)

Precautions

• Evaluate cardiovascular status before initiating therapy.

• Avoid excessive alcohol intake, which may potentiate hypotension.

• Use caution in patients with anatomical penile deformities or predisposition to priapism.

• Concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) requires dose adjustment.

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Possible Adverse Reactions

Most side effects are mild-to-moderate and self-limiting:

Seek medical assistance if an erection persists longer than four hours or if severe adverse symptoms occur.

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Drug Interactions

• Nitrates: Severe hypotension risk – contraindicated.

• Alpha-blockers: Additive vasodilatory effect – monitor BP.

• Antihypertensives: May potentiate hypotensive response.

• Strong CYP3A4 inhibitors/inducers: Modify tadalafil plasma concentrations.

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Storage and Handling

• Store at below 30 °C, in a cool, dry place away from moisture and direct light.

• Keep out of reach of children.

• Do not use after expiry date.

• Dispose of unused medication per local pharmaceutical guidelines.

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Clinical Evidence

Multiple double-blind, placebo-controlled trials demonstrate tadalafil’s superior efficacy and tolerability in ED management. Mean success rates in achieving satisfactory erections exceed 70–80 %, including among men with diabetes mellitus or post-prostatectomy status.

Pharmacodynamic studies confirm onset within 30 minutes and sustained effect up to 36 hours, allowing enhanced sexual spontaneity.

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Why Choose Vidalista 80 mg?

• High-strength formulation: suitable for patients requiring greater therapeutic response under physician supervision.

• Reliable performance: long duration ensures confidence and planning flexibility.

• Manufacturing assurance: produced under GMP-certified conditions ensuring quality, purity, and bioequivalence.

• Trusted global brand: Centurion Remedies products are distributed worldwide with consistent clinical reputation.